Fermentation Submerged fermentation (SmF) utilizes free flowing liquid substrates, such as corn steep liquor, molasses and nutrient broths. The enzymes and bioactive compounds are secreted into the fermentation broth. The substrates are utilized quite rapidly and hence need to be constantly supplemented with nutrients. This fermentation technique is best suited for microorganisms such as bacteria that require high moisture.
At Karyotica we have developed cutting edge SmF platform for production various enzymes and many other biocatalysts. All our recombinant range of enzymes are mainly produced through SmF process. We further use SmF for the production of a range of probiotics at our state of the art GMP facility and constantly investigate into methodologies and processes which result in higher yields and better product attributes.